1. Overview

Gene fusion is one of the most common somatic alterations that plays an important role in tumorgenesis. Well-known examples include the intra-chromosomal TMPRSS2-ERG fusions in prostate cancer, and the inter-chromosomal BCR-ABL fusions in chronic myelogenous leukemia (CML). With the advent of next generation sequencing technologies especially RNA-seq and the development of dozens of fusion detection tools, most recurrent gene fusions in common cancers have been identified. These fusion are cataloged in databases such as COSMIC , FusionGDB , FusionHub, ChimerDB and TumorFusions ).

To facilitate molecular testing, we developed FusionVet (Fusion Visualization and Evaluation Tool) to quickly (and accurately) examine if a gene fusion with clinical significance exists in a particular sample or not.